| Tittel: | Adverse effects of psychotropic drugs in old age | | Signatur: | Elektronisk dokument | | Ansvar: | Jon Brännström | | Forfatter: | Brännström, Jon  | | Materialtype: | Elektronisk dokument | | Utgitt: | Umeå : Umeå University, Department of Community Medicine and Rehabilitation, Geriatric Medicine, 2020 | | Omfang: | 127 s. | | Emneord: | Bivirkninger / Dødelighet / Eldre / Geriatri / Hoftebrudd / Legemiddelbruk / Legemidler / Psykiatriske pasienter / Psykiske lidelser / Psykofarmaka / Risikofaktorer / Skadevirkninger | | Innhold: | Background: With increasing age, the body and mind transform. Many of our organs gradually lose capacity, making them more sensitive to the effects of several drugs. In parallel, many of us accumulate an increasing burden of disease and other conditions warranting the use of medications. Hence, the use of most classes of drugs increases with age, especially so in elderly women.At the same time, medical science is lagging behind due to the fact that the oldest people in society often are excluded from pharmacological studies, where young males are the most coveted subjects.In the absence of strong evidence, much of the knowledge about the clinical and adverse effects of several drugs in the elderly is derived from observational studies, prone to bias and confounding. The use of psychotropic drugs in elderly people is particularly controversial, and even more so in people suffering from major neurocognitive disorders (NCD). Psychotropics have been associated with several adverse effects as well as limited clinical effect. Still, they are frequently prescribed to elderly patients.
The evidence supporting causal relationships between psychotropic drug use and serious adverse events in old age is insufficient. Our results point towards bias and confounding having strong influences on the observed associations between psychotropic drug use and mortality, and hip fracture, respectively. | | Eier: | HELSTILS |
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